Peptides have been the subject of much discussion. They are a keystay in treating acute and chronic conditions. Peptides are becoming a more popular treatment option as the environment and landscape changes rapidly. There are currently 140 clinical trials with peptides and 500 pre-clinical studies that are being conducted. Over 60 peptide drugs have been approved by the FDA as of today. They are safe, effective, and specific with few to no side effects. Peptides are made primarily of amino acids. Combining different amino acids can result in different types of peptides. Different proteins can be formed when peptides become linked. Historical note: Insulin was the first peptide to be introduced on the market in 1921.

The benefits of peptides can be used to improve wellbeing, aging, or repair. We lose the ability to make growth hormone (GH) when we consider any type of disease or actual aging process from the 1920s to the 1930s. Growth hormone (GH) is the final hormone that controls the relative regulation and manipulations of the mitochondria and the immune system, as well as the immune-regulating cells.

The ability to produce growth hormone is lost. This has an immediate effect on cells, mitochondria function, and immune function.

WHAT AGING CAN DO FOR YOU

1. Increased Oxidative Status

• Increased ROS (Reactive Oxygen Species) and free radicals
• Disruption in redox signaling – this causes damage to the mitochondria, which in turn causes inactivation regulatory enzymes, abnormal cell growth, division and death.

2. Mitochondrial Dysfunction

• Reduced production of sex steroids
• A decrease in growth, inflammation and immune transcription factors
• Apoptosis of cells has declined
• Stem cell activations are declining

3. Catabolic State Increased

• Reduced immunity function
• Diminished PH
• Increased bone demineralization
• Increased sarcopenia
• Reduced nutrient intake (loss appetite)

• Energy loss
• Loss of sleep (loss of cognitive and restorative function)
• Sedentary lifestyles are increasing
• Depression

WHAT PEPTIDES DO TO COMBAT AGING

There are many different peptides that work in different parts of the body. Understanding how our bodies work is the first step. The pituitary gland is located at the base of the brain. Although it is tiny, the pituitary is responsible for controlling other hormonal glands, such as adrenals and thyroid. These glands are crucial in maintaining a healthy body and overall wellbeing.

The pituitary gland produces growth hormone directly. We can recreate the potential for growth hormone release in a normal bodily function (physiologic) form using peptides. Some peptides stimulate certain receptors in the pituitary. These peptides can stimulate the body to make isoforms of growth hormone. They are different types depending on what you need. Our bodies naturally produce their own growth hormone. The physiologic production can be restored to the level it was when we were 30,

No matter how old you are, whether you’re 40 or 60 years old or 80, your anterior pituitary will still produce the same amount as when we were 20, provided it is stimulated appropriately. The machinery that produces growth hormone is not lost; it’s just that aging causes issues in the release of growth hormone.

Understanding the benefits of anti-aging is key. The body’s growth hormone is involved in many different tissues. It can stimulate bone and cartilage growth in children and adolescents.

It can increase protein production and fat utilization in all ages.

GH also increases insulin-like growth factors-1 (IGF-1), which are important for the development of lean muscles. This negative feedback loop causes decreased natural production of GH from pituitary.

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